TCR agonist and antagonist exert in vivo cross-regulation when presented on Igs.

Cross-Regulation When Presented on Igs TCR Agonist and Antagonist Exert In Vivo

Cooperation or sabotage? Self-peptide-MHC complexes influence T-cell responses to antigens.

In their Opinion, Ge et al. [1] reviewed some recent published data on the role of self-peptide–MHC complexes in the modulation of immune responses to antigens. The authors suggest that some ‘inconsistencies’ in published findings could be attributed to potential aberrant expression of unusual MHC class II molecules (composed of Ab and Ea chains) in MHC class II-deficient mice used by Bhandoola...

Presentation of a T Cell Receptor Antagonist Peptide by Immunoglobulins Ablates Activation of  T Cells by a Synthetic Peptide or Proteins Requiring Endocytic Processing

T cell receptor (TCR) antagonism is being considered for inactivation of aggressive T cells and reversal of T cell-mediated autoimmune diseases. TCR antagonist peptides silence aggressive T cells and reverse experimental allergic encephalomyelitis induced with free peptides. However, it is not clear whether free antagonist peptides could reverse natural disease where the antigen is presumably a...

Repeated administration of cannabinoid receptor agonist and antagonist impairs short and long term plasticity of rat’s dentate gyrus in vivo

Introduction: The effects of cannabinoids (CBs) on synaptic plasticity of hippocampal dentate gyrus neurons have been shown in numerous studies. However, the effect of repeated exposure to cannabinoids on hippocampal function is not fully understood. In this study, using field potential recording, we investigated the effect of repeated administration of the nonselective CB receptor agonist WIN5...

The Eeffect of Coasting on Intracytoplasmic Sperm Injection Outcome in Antagonist and Agonist Cycle

Objective Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with coasting on the parameters of ICSI cycles and the outcome. M...